Muisca is a South American Tribal Monarchy in the Andean technology group. It occupies a unique position among Andean countries in that it is surrounded by empty provinces. In 1444, it owns 3 provinces. Historically, the Muisca were the source of the El Dorado legends.
Events for the Muisca revolve around the Muisca's two historical leadership positions, the Zipa and the Zaque.
The Muisca occupy a unique position and as such have unique opportunities. The first decision to make is whether to support the Zippa or the Zaque in the first flavour event, which Muisca gets within a few months of starting the game. It doesn't matter which choice is made; both options are equally viable. Whichever Muisca picks, the player should aim to have a military force capable of defeating the size 2 pretender rebels that spawn every time Musica gets a new ruler. The player also want to pick the "The time has come to act together." option for the Influence of the Iraca event when it becomes available, since the extra ADM points aid in maintaining stability.
There are two ways to expand. Firstly, Muisca could declare a no-CB war against one of the other Andean nations to the South. This can be a good option depending on the situation in that region, but it can also be risky. Unlike other nations outside of the main Andean region, Muisca's technology group puts them on the same level as others in the region, so Muisca doesn't need to fear falling behind the Incas in military tech. The other way to expand is to get to ADM tech 5 as quickly as possible so that Muisca can pick up Exploration ideas. Muisca could use ADM and then DIP monarch point focus to achieve this faster. This will give Muisca colonists. Muisca could move towards the other Andean countries for ease of conquest. Later on it will be advantageous to move North and East; this will bring Muisca closer to European colonists.